Abstract
Mutations in SOX9 are associated with male-to-female sex reversal in humans1,2. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
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Acknowledgements
We thank U. Ziegler, S. Schmidt, S. Lützkendorf and D. Landrock for excellent technical assistance. This work was supported by the Volkswagen Stiftung and EC-grant QLRT00741.
Author information
Andreas Schedl
Present address: Institute of Human Genetics, University of Newcastle upon Tyne, UK
Valerie P.I. Vidal and Marie-Christine Chaboissier: These authors contributed equally to this work.
Authors and Affiliations
MDC for Molecular Medicine, Robert-Rössle-Strasse 10, Berlin, 13092, Germany
Valerie P.I. Vidal, Marie-Christine Chaboissier & Andreas Schedl
Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands
Dirk G. de Rooij
- Valerie P.I. Vidal
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- Marie-Christine Chaboissier
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- Dirk G. de Rooij
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- Andreas Schedl
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Correspondence to Andreas Schedl.
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Vidal, V., Chaboissier, MC., de Rooij, D. et al. Sox9 induces testis development in XX transgenic mice. Nat Genet 28, 216–217 (2001). https://doi.org/10.1038/90046
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DOI: https://doi.org/10.1038/90046
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