$ wget https://bitbucket.org/pypy/pypy/downloads/pypy3-v6.0.0-linux64.tar.bz2
$ tar jxf pypy3-v6.0.0-linux64.tar.bz2
$ mkdir ./venv_pypy
$ virtualenv -p ./pypy3-v6.0.0-linux64/bin/pypy3 ./venv_pypy
$ source ./venv_pypy/bin/activate
$ pip install rsa==4.1
Collecting rsa==4.1
  Using cached rsa-4.1-py3-none-any.whl (32 kB)
Requirement already satisfied: pyasn1>=0.1.3 in ./venv_pypy/site-packages (from rsa==4.1) (0.4.8)
Collecting pysha3<2.0,>=1.0; python_version >= "3.5" and python_version < "3.6"
  Using cached pysha3-1.0.2.tar.gz (829 kB)
Building wheels for collected packages: pysha3
  Building wheel for pysha3 (setup.py) ... error
  ERROR: Command errored out with exit status 1:
   command: /home/develop/venv_pypy/bin/pypy3 -u -c 'import sys, setuptools, tokenize; sys.argv[0] = '"'"'/tmp/pip-install-9q7018wt/pysha3/setup.py'"'"'; __file__='"'"'/tmp/pip-install-9q7018wt/pysha3/setup.py'"'"';f=getattr(tokenize, '"'"'open'"'"', open)(__file__);code=f.read().replace('"'"'\r\n'"'"', '"'"'\n'"'"');f.close();exec(compile(code, __file__, '"'"'exec'"'"'))' bdist_wheel -d /tmp/pip-wheel-fza3daue
       cwd: /tmp/pip-install-9q7018wt/pysha3/
  Complete output (16 lines):
  running bdist_wheel
  running build
  running build_py
  creating build
  creating build/lib.linux-x86_64-3.5
  copying sha3.py -> build/lib.linux-x86_64-3.5
  running build_ext
  building '_pysha3' extension
  creating build/temp.linux-x86_64-3.5
  creating build/temp.linux-x86_64-3.5/Modules
  creating build/temp.linux-x86_64-3.5/Modules/_sha3
  cc -pthread -DNDEBUG -O2 -fPIC -DPY_WITH_KECCAK=1 -I/home/develop/venv_pypy/pypy3-v6.0.0-linux64/include -c Modules/_sha3/sha3module.c -o build/temp.linux-x86_64-3.5/Modules/_sha3/sha3module.o
  In file included from Modules/_sha3/sha3module.c:20:0:
  Modules/_sha3/backport.inc:78:22: fatal error: pystrhex.h: No such file or directory
  compilation terminated.
  error: command 'cc' failed with exit status 1
  ----------------------------------------
  ERROR: Failed building wheel for pysha3
  Running setup.py clean for pysha3
Failed to build pysha3
Installing collected packages: pysha3, rsa
    Running setup.py install for pysha3 ... error
    ERROR: Command errored out with exit status 1:
     command: /home/develop/venv_pypy/bin/pypy3 -u -c 'import sys, setuptools, tokenize; sys.argv[0] = '"'"'/tmp/pip-install-9q7018wt/pysha3/setup.py'"'"'; __file__='"'"'/tmp/pip-install-9q7018wt/pysha3/setup.py'"'"';f=getattr(tokenize, '"'"'open'"'"', open)(__file__);code=f.read().replace('"'"'\r\n'"'"', '"'"'\n'"'"');f.close();exec(compile(code, __file__, '"'"'exec'"'"'))' install --record /tmp/pip-record-pjjhc4qx/install-record.txt --single-version-externally-managed --compile --install-headers /home/develop/venv_pypy/include/site/python3.5/pysha3
         cwd: /tmp/pip-install-9q7018wt/pysha3/
    Complete output (16 lines):
    running install
    running build
    running build_py
    creating build
    creating build/lib.linux-x86_64-3.5
    copying sha3.py -> build/lib.linux-x86_64-3.5
    running build_ext
    building '_pysha3' extension
    creating build/temp.linux-x86_64-3.5
    creating build/temp.linux-x86_64-3.5/Modules
    creating build/temp.linux-x86_64-3.5/Modules/_sha3
    cc -pthread -DNDEBUG -O2 -fPIC -DPY_WITH_KECCAK=1 -I/home/develop/venv_pypy/pypy3-v6.0.0-linux64/include -c Modules/_sha3/sha3module.c -o build/temp.linux-x86_64-3.5/Modules/_sha3/sha3module.o
    In file included from Modules/_sha3/sha3module.c:20:0:
    Modules/_sha3/backport.inc:78:22: fatal error: pystrhex.h: No such file or directory
    compilation terminated.
    error: command 'cc' failed with exit status 1
    ----------------------------------------
ERROR: Command errored out with exit status 1: /home/develop/venv_pypy/bin/pypy3 -u -c 'import sys, setuptools, tokenize; sys.argv[0] = '"'"'/tmp/pip-install-9q7018wt/pysha3/setup.py'"'"'; __file__='"'"'/tmp/pip-install-9q7018wt/pysha3/setup.py'"'"';f=getattr(tokenize, '"'"'open'"'"', open)(__file__);code=f.read().replace('"'"'\r\n'"'"', '"'"'\n'"'"');f.close();exec(compile(code, __file__, '"'"'exec'"'"'))' install --record /tmp/pip-record-pjjhc4qx/install-record.txt --single-version-externally-managed --compile --install-headers /home/develop/venv_pypy/include/site/python3.5/pysha3 Check the logs for full command output.