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GeezerVison is showing web.expasy.org — UniProtKB/Swiss-Prot Release 2026_04 statistics
UniProtKB/Swiss-Prot protein knowledgebase release 2026_04 statistics
1. INTRODUCTION
Release 2026_04 of 04-Nov-2026 of UniProtKB/Swiss-Prot contains 576073 sequence
entries, curated from 314855 unique references and comprising 209202719 amino acids.
332 sequences have been added since release 2026_03, the sequence data of
25 existing entries has been updated and the annotations of
506048 entries have been revised.
Number of fragments: 9309
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 41374
Protein existence (PE): entries %
1: Evidence at protein level 122069 21.2%
2: Evidence at transcript level 54392 9.4%
3: Inferred from homology 385236 66.9%
4: Predicted 12646 2.2%
5: Uncertain 1730 0.3%
The growth of the database is summarized below.
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2. TAXONOMIC ORIGIN
Total number of species represented in this release of UniProtKB/Swiss-Prot: 14947
The first twenty species represent 123524 sequences: 21.4 % of the total
number of entries.
2.1 Table of the frequency of occurrence of species
Species represented 1x: 6083
2x: 2167
3x: 1177
4x: 797
5x: 553
6x: 443
7x: 339
8x: 293
9x: 241
10x: 159
11- 20x: 865
21- 50x: 529
51-100x: 237
>100x: 1064
2.2 Table of the most represented species
------ --------- --------------------------------------------
Number Frequency Species
------ --------- --------------------------------------------
1 20429 Homo sapiens (Human)
2 17285 Mus musculus (Mouse)
3 16421 Arabidopsis thaliana (Mouse-ear cress)
4 8239 Rattus norvegicus (Rat)
5 6733 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
6 6055 Bos taurus (Bovine)
7 5129 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
8 4531 Escherichia coli (strain K12)
9 4490 Caenorhabditis elegans
10 4197 Oryza sativa subsp. japonica (Rice)
11 4191 Bacillus subtilis (strain 168)
12 4163 Dictyostelium discoideum (Social amoeba)
13 3912 Drosophila melanogaster (Fruit fly)
14 3523 Xenopus laevis (African clawed frog)
15 3388 Danio rerio (Zebrafish) (Brachydanio rerio)
16 2355 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
17 2318 Gallus gallus (Chicken)
18 2218 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
19 2048 Escherichia coli O157:H7
20 1899 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
21 1833 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
22 1786 Methanocaldococcus jannaschii
23 1714 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
24 1703 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
25 1702 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
26 1699 Shigella flexneri
27 1506 Pseudomonas aeruginosa
28 1463 Sus scrofa (Pig)
29 1349 Salmonella typhi
30 1244 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
31 1198 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
32 1176 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
33 1115 Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
34 1038 Archaeoglobus fulgidus
35 1035 Aspergillus nidulans
36 1031 Yersinia pestis
37 1000 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
38 982 Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
39 982 Neurospora crassa
40 979 Oryctolagus cuniculus (Rabbit)
41 945 Staphylococcus aureus (strain Mu50 / ATCC 700699)
42 930 Staphylococcus aureus (strain N315)
43 930 Salmonella paratyphi A (strain ATCC 9150 / SARB42)
44 929 Eremothecium gossypii
45 920 Kluyveromyces lactis
46 909 Acanthamoeba polyphaga mimivirus (APMV)
47 905 Staphylococcus aureus (strain COL)
48 896 Staphylococcus aureus (strain MW2)
49 894 Escherichia coli O6:K15:H31 (strain 536 / UPEC)
50 892 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
51 891 Candida glabrata
52 890 Staphylococcus aureus (strain MSSA476)
53 888 Staphylococcus aureus (strain MRSA252)
54 882 Salmonella choleraesuis (strain SC-B67)
55 879 Shigella sonnei (strain Ss046)
56 877 Oryza sativa subsp. indica (Rice)
57 863 Yersinia pseudotuberculosis serotype I (strain IP32953)
58 857 Canis lupus familiaris (Dog) (Canis familiaris)
59 850 Zea mays (Maize)
60 847 Escherichia coli O9:H4 (strain HS)
61 838 Escherichia coli O139:H28 (strain E24377A / ETEC)
62 829 Shigella boydii serotype 4 (strain Sb227)
63 825 Escherichia coli (strain UTI89 / UPEC)
64 823 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
65 822 Shigella dysenteriae serotype 1 (strain Sd197)
66 822 Escherichia coli
67 817 Staphylococcus aureus (strain NCTC 8325 / PS 47)
68 804 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
69 798 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
70 791 Escherichia coli (strain SMS-3-5 / SECEC)
71 788 Aquifex aeolicus (strain VF5)
72 779 Escherichia coli O127:H6 (strain E2348/69 / EPEC)
73 771 Escherichia coli (strain K12 / DH10B)
74 770 Pasteurella multocida (strain Pm70)
75 767 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
76 765 Escherichia coli (strain K12 / MC4100 / BW2952)
77 762 Escherichia coli (strain 55989 / EAEC)
78 761 Escherichia coli O8 (strain IAI1)
79 760 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
80 760 Shigella flexneri serotype 5b (strain 8401)
81 760 Staphylococcus epidermidis
82 759 Escherichia coli O45:K1 (strain S88 / ExPEC)
83 758 Bacillus anthracis
84 756 Escherichia coli (strain SE11)
85 753 Escherichia coli O7:K1 (strain IAI39 / ExPEC)
86 749 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
87 748 Escherichia coli O157:H7 (strain EC4115 / EHEC)
88 745 Pseudomonas putida
89 745 Escherichia coli
90 744 Halalkalibacterium halodurans
91 739 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
92 733 Vibrio vulnificus (strain CMCP6)
93 731 Escherichia coli O81 (strain ED1a)
94 722 Salmonella enteritidis PT4 (strain P125109)
95 721 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
96 718 Vibrio vulnificus (strain YJ016)
97 716 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
98 715 Yersinia pestis bv. Antiqua (strain Nepal516)
99 715 Enterobacter sp. (strain 638)
100 715 Escherichia coli O1:K1 / APEC
101 714 Salmonella paratyphi A (strain AKU_12601)
102 713 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
103 713 Salmonella newport (strain SL254)
104 713 Salmonella agona (strain SL483)
105 712 Salmonella schwarzengrund (strain CVM19633)
106 711 Yersinia pestis bv. Antiqua (strain Antiqua)
107 710 Salmonella heidelberg (strain SL476)
108 708 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
109 702 Salmonella dublin (strain CT_02021853)
110 699 Klebsiella variicola (strain 342) (Klebsiella pneumoniae)
111 698 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
112 695 Escherichia fergusonii
113 693 Pan troglodytes (Chimpanzee)
114 686 Mycoplasmoides pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
115 684 Staphylococcus aureus (strain USA300)
116 684 Salmonella gallinarum (strain 287/91 / NCTC 13346)
117 683 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
118 680 Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
119 679 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
120 672 Serratia proteamaculans (strain 568)
121 672 Bacillus cereus
122 670 Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
123 669 Mycobacterium leprae (strain TN)
124 667 Yersinia pestis (strain Pestoides F)
125 667 Bradyrhizobium diazoefficiens
126 663 Shewanella oneidensis
127 658 Sinorhizobium fredii (strain NBRC 101917 / NGR234)
128 653 Debaryomyces hansenii
129 643 Staphylococcus aureus (strain bovine RF122 / ET3-1)
130 642 Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
131 642 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
132 634 Yersinia pseudotuberculosis serotype IB (strain PB1/+)
133 628 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
134 623 Methanothermobacter thermautotrophicus
135 623 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
136 623 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
137 622 Treponema pallidum (strain DSM 117211 / Nichols)
138 621 Pseudomonas aeruginosa (strain UCBPP-PA14)
139 617 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
140 615 Xanthomonas campestris pv. campestris
141 614 Staphylococcus haemolyticus (strain JCSC1435)
142 614 Mesorhizobium japonicum (Mesorhizobium loti
143 605 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
144 604 Ralstonia nicotianae (strain ATCC BAA-1114 / GMI1000) (Ralstonia solanacearum)
145 602 Staphylococcus saprophyticus subsp. saprophyticus
146 602 Photobacterium profundum (strain SS9)
147 601 Salmonella paratyphi C (strain RKS4594)
148 600 Yersinia pestis bv. Antiqua (strain Angola)
149 597 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
150 596 Bacillus cereus (strain ATCC 10987 / NRS 248)
151 592 Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
152 591 Pectobacterium carotovorum subsp. carotovorum (strain PC1)
153 584 Rickettsia prowazekii (strain Madrid E)
154 582 Caenorhabditis briggsae
155 579 Brucella suis biovar 1 (strain 1330)
156 577 Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15)
157 576 Brucella melitensis biotype 1
158 573 Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
159 572 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
160 569 Bacillus thuringiensis subsp. konkukian (strain 97-27)
161 569 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
162 569 Thermotoga maritima
163 568 Pseudomonas syringae pv. syringae (strain B728a)
164 567 Bacillus licheniformis
165 562 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
166 562 Bacillus cereus (strain ZK / E33L)
167 561 Xanthomonas citri pv. citri (strain 306)
168 559 Clostridium acetobutylicum
169 555 Pseudomonas fluorescens (strain Pf0-1)
170 554 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
171 554 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
172 553 Oceanobacillus iheyensis
173 547 Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv. phaseolicola
174 543 Corynebacterium glutamicum
175 541 Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
176 535 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
177 531 Erwinia tasmaniensis
178 531 Staphylococcus aureus (strain Newman)
179 530 Listeria monocytogenes serotype 4b (strain F2365)
180 529 Sodalis glossinidius (strain morsitans)
181 525 Deinococcus radiodurans
182 523 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
183 522 Xylella fastidiosa (strain 9a5c)
184 520 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
185 519 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
186 519 Chromobacterium violaceum
187 518 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
188 518 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
189 515 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
190 515 Xylella fastidiosa (strain Temecula1 / ATCC 700964)
191 512 Pseudomonas paraeruginosa (strain DSM 24068 / PA7) (Pseudomonas aeruginosa
192 512 Haemophilus ducreyi (strain 35000HP / ATCC 700724)
193 512 Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
194 512 Geobacillus kaustophilus (strain HTA426)
195 511 Streptomyces avermitilis
196 509 Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
197 508 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
198 507 Nicotiana tabacum (Common tobacco)
199 507 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
200 505 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
201 504 Pseudomonas entomophila (strain DSM 28517 / CCUG 61470 / CECT 7985 / L48)
202 503 Haemophilus influenzae (strain 86-028NP)
203 502 Methanosarcina mazei
204 501 Burkholderia pseudomallei (strain K96243)
205 500 Pyrococcus horikoshii
206 499 Brucella abortus biovar 1 (strain 9-941)
207 498 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
208 497 Xanthomonas campestris pv. campestris (strain 8004)
209 497 Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805)
210 497 Proteus mirabilis (strain HI4320)
211 496 Shouchella clausii (strain KSM-K16) (Alkalihalobacillus clausii)
212 496 Rickettsia conorii (strain ATCC VR-613 / Malish 7)
213 495 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
214 495 Brucella abortus (strain 2308)
215 492 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)
216 491 Vibrio campbellii (strain ATCC BAA-1116)
217 488 Shewanella sp. (strain MR-7)
218 486 Mannheimia succiniciproducens (strain KCTC 0769BP / MBEL55E)
219 486 Cupriavidus necator
220 485 Pseudomonas aeruginosa (strain LESB58)
221 485 Shewanella sp. (strain MR-4)
222 484 Staphylococcus aureus (strain Mu3 / ATCC 700698)
223 484 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
224 483 Mycoplasmoides genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
225 481 Pyrococcus abyssi (strain GE5 / Orsay)
226 480 Pseudomonas putida
227 478 Enterococcus faecalis (strain ATCC 700802 / V583)
228 476 Campylobacter jejuni subsp. jejuni serotype O:2
229 475 Burkholderia lata
230 473 Cereibacter sphaeroides
231 472 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
232 470 Clostridium perfringens (strain 13 / Type A)
233 468 Shewanella frigidimarina (strain NCIMB 400)
234 468 Pseudomonas putida (strain GB-1)
235 468 Shewanella sp. (strain ANA-3)
236 467 Aeromonas hydrophila subsp. hydrophila
237 466 Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)
238 466 Xanthomonas euvesicatoria pv. vesicatoria (strain 85-10)
239 463 Burkholderia mallei (strain ATCC 23344)
240 462 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
241 461 Ovis aries (Sheep)
242 460 Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
243 457 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
244 455 Shewanella baltica (strain OS185)
245 455 Staphylococcus aureus (strain JH1)
246 455 Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
247 453 Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
248 453 Pseudomonas putida (strain W619)
249 453 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
250 452 Aeromonas salmonicida (strain A449)
2.3 Taxonomic distribution of the sequences
Kingdom sequences (% of the database)
Archaea 19926 ( 3%)
Bacteria 337425 ( 59%)
Eukaryota 201181 ( 35%)
Viruses 17541 ( 3%)
Within Eukaryota:
Category sequences (% of Eukaryota) (% of the complete database)
Human 20430 ( 10%) ( 4%)
Other Mammalia 47583 ( 24%) ( 8%)
Other Vertebrata 19109 ( 9%) ( 3%)
Viridiplantae 42110 ( 21%) ( 7%)
Fungi 38561 ( 19%) ( 7%)
Insecta 10190 ( 5%) ( 2%)
Nematoda 5409 ( 3%) ( 1%)
Other 17789 ( 9%) ( 3%)
3. SEQUENCE SIZE
Repartition of the sequences by size (excluding fragments)
From To Number From To Number
1- 50 10082 1001-1100 4206
51- 100 43906 1101-1200 2949
101- 150 60198 1201-1300 2243
151- 200 59917 1301-1400 2100
201- 250 58814 1401-1500 1715
251- 300 52883 1501-1600 854
301- 350 53368 1601-1700 653
351- 400 46434 1701-1800 613
401- 450 38045 1801-1900 549
451- 500 30932 1901-2000 407
501- 550 22688 2001-2100 285
551- 600 16036 2101-2200 401
601- 650 13304 2201-2300 351
651- 700 9517 2301-2400 245
701- 750 7970 2401-2500 214
751- 800 5784 >2500 1548
801- 850 4973
851- 900 5360
901- 950 4169
951-1000 3051
The average sequence length in UniProtKB/Swiss-Prot is 363 amino acids.
The shortest sequence is GWA_SEPOF (P83570): 2 amino acids.
The longest sequence is TITIN_MOUSE (A2ASS6): 35213 amino acids.
4. JOURNAL CITATIONS
Note: the following citation statistics reflect the number of distinct
journal citations.
Total number of journals cited in this release of UniProtKB/Swiss-Prot: 3291
4.1 Table of the frequency of journal citations
Journals cited 1x: 1014
2x: 440
3x: 237
4x: 156
5x: 138
6x: 96
7x: 70
8x: 66
9x: 71
10x: 36
11- 20x: 258
21- 50x: 281
51-100x: 151
>100x: 277
4.2 List of the most cited journals in UniProtKB/Swiss-Prot
Nb Citations Journal name
-- --------- -------------------------------------------------------------
1 28281 Journal of Biological Chemistry
2 13376 Proceedings of the National Academy of Sciences of the U.S.A.
3 7475 Journal of Bacteriology
4 6249 Biochemical and Biophysical Research Communications
5 6104 Biochemistry
6 5560 Nucleic Acids Research
7 5528 Nature
8 5202 FEBS Letters
9 5145 The EMBO Journal
10 4925 Gene
11 4767 Journal of Molecular Biology
12 4689 Molecular and Cellular Biology
13 4170 Biochimica et Biophysica Acta
14 4044 Cell
15 3736 Journal of Virology
16 3593 Science
17 3556 European Journal of Biochemistry
18 3297 Biochemical Journal
19 3039 Molecular Microbiology
20 2914 PLoS ONE
21 2849 Plant Physiology
22 2550 Genomics
23 2514 The American Journal of Human Genetics
24 2458 Journal of Cell Biology
25 2225 The Plant Cell
26 2102 Human Molecular Genetics
27 2057 The Plant Journal
28 2025 Molecular Cell
29 2004 Genes and Development
30 1950 Virology
31 1932 Plant Molecular Biology
32 1912 Nature Communications
33 1891 Molecular Biology of the Cell
34 1890 Nature Genetics
35 1886 Development
36 1784 Journal of Immunology
37 1701 Human Mutation
38 1584 Oncogene
39 1533 Structure
40 1461 Genetics
41 1459 Journal of Biochemistry
42 1450 Journal of Cell Science
43 1445 Molecular and General Genetics
44 1336 Blood
45 1315 Infection and Immunity
46 1230 Microbiology
47 1216 Developmental Biology
48 1204 Journal of General Virology
49 1192 Archives of Biochemistry and Biophysics
50 1186 Current Biology
51 1164 Scientific Reports
52 1099 Applied and Environmental Microbiology
53 1098 Journal of Neuroscience
54 1023 Acta Crystallographica, Section D
55 995 PLoS Genetics
56 981 FEMS Microbiology Letters
57 944 Cancer Research
58 926 American Journal of Physiology
59 926 Toxicon
60 919 Protein Science
61 910 Journal of Clinical Investigation
62 869 Neuron
63 862 Yeast
64 813 The Journal of Experimental Medicine
65 804 PLoS Pathogens
66 796 Nature Structural and Molecular Biology
67 781 Human Genetics
68 780 Plant and Cell Physiology
69 755 The FEBS Journal
70 752 Journal of Medical Genetics
71 727 Proteins
72 702 Nature Cell Biology
73 687 Mechanisms of Development
74 669 Bioscience, Biotechnology, and Biochemistry
75 668 Antimicrobial Agents and Chemotherapy
76 658 Cell Reports
77 656 Nature Structural Biology
78 633 Developmental Cell
79 622 Current Genetics
80 595 Journal of Neurochemistry
81 595
82 590 Journal of the American Chemical Society
83 569 Molecular Endocrinology
84 565 The Journal of Clinical Endocrinology and Metabolism
85 561 Endocrinology
86 554 Molecular and Biochemical Parasitology
87 522 Eukaryotic Cell
88 518 EMBO Reports
89 509 Experimental Cell Research
90 503 RNA
91 502 American Journal of Medical Genetics. Part A
92 497 The FASEB Journal
93 496 Mammalian Genome
94 488 Peptides
95 480 Journal of Experimental Botany
96 465 Planta
97 458 Molecular Pharmacology
98 456 Acta Crystallographica, Section F
99 454 European Journal of Human Genetics
100 451 Clinical Genetics
101 439 Molecular Plant-Microbe Interactions
102 435 Immunogenetics
103 431 Immunity
104 428 Journal of Investigative Dermatology
105 426 Molecular Biology and Evolution
106 409 Journal of Molecular Evolution
107 407 Biochimie
108 406 Neurology
109 400 DNA and Cell Biology
110 392 Biology of Reproduction
111 384 PLoS Biology
112 383 Applied Microbiology and Biotechnology
113 383 Comparative Biochemistry and Physiology
114 381 DNA Sequence
115 375 Genes to Cells
116 372 Nature Immunology
117 368 Journal of Medicinal Chemistry
118 367 Virus Research
119 367 BMC Genomics
120 364 Journal of Lipid Research
121 350 Developmental Dynamics
122 348 The New England Journal of Medicine
123 345 Annals of Neurology
124 343 Brain Research. Molecular Brain Research
125 332 Nature Chemical Biology
126 332 European Journal of Immunology
127 325 Investigative Ophthalmology and Visual Science
128 324 Journal of Human Genetics
129 323 Genome Research
130 311 Brain
131 303 Fungal Genetics and Biology
132 300 Glycobiology
133 299 Biological Chemistry Hoppe-Seyler
134 287 Archives of Microbiology
135 285 Journal of General Microbiology
136 284 Traffic
137 282 Cell Research
138 280 Cytogenetics and Cell Genetics
139 273 Protein Expression and Purification
140 272 Molecular Genetics and Metabolism
141 271 Nature Medicine
142 267 Molecular Immunology
143 264 Phytochemistry
144 259 Frontiers in Microbiology
145 258 Journal of Cellular Biochemistry
146 255 Cell Cycle
147 252 Insect Biochemistry and Molecular Biology
148 250 Circulation Research
149 247 ChemBioChem
150 246 New Phytologist
5. STATISTICS FOR SOME LINE TYPES
The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.
Total Number of Average
Line type / subtype number entries per entry
------------------------------------ -------- --------- ---------
References (RL) 1365783 2.37
Journal 1179114 483059 2.05 1
Submitted to EMBL/GenBank/DDBJ 174901 151266 0.30 2
Submitted to other databases 8031 7293 0.01 3
Book citation 1881 1858 <0.01 4
Plant Gene Register 613 600 <0.01 5
Unpublished observations 544 540 <0.01 6
Thesis 477 474 <0.01 7
Patent 216 209 <0.01 8
Worm Breeder's Gazette 6 6 <0.01 9
Total number of distinct authors cited in UniProtKB/Swiss-Prot: 497280
Total Number of Average
Line type / subtype number entries per entry Rank
------------------------------------ -------- --------- --------- ----
Comments (CC) 2833271 4.92
ACTIVITY REGULATION 20080 19937 0.03 17
ALLERGEN 980 980 <0.01 26
ALTERNATIVE PRODUCTS 26052 26052 0.05 14
BIOPHYSICOCHEMICAL PROPERTIES 12773 12708 0.02 20
BIOTECHNOLOGY 2494 2428 <0.01 24
CATALYTIC ACTIVITY 365644 260819 0.63 4
CAUTION 14869 14548 0.03 19
COFACTOR 138861 126291 0.24 7
DEVELOPMENTAL STAGE 15012 14872 0.03 18
DISEASE 8783 5890 0.02 21
DISRUPTION PHENOTYPE 24436 24358 0.04 16
DOMAIN 64986 54427 0.11 9
FUNCTION 505049 476489 0.88 2
INDUCTION 27641 27514 0.05 13
INTERACTION 25415 25415 0.04 15
MASS SPECTROMETRY 7747 5998 0.01 22
MISCELLANEOUS 46863 41178 0.08 11
PATHWAY 145631 131544 0.25 6
PHARMACEUTICAL 165 158 <0.01 29
POLYMORPHISM 1519 1396 <0.01 25
PTM 68689 48138 0.12 8
RNA EDITING 646 646 <0.01 28
SEQUENCE CAUTION 45583 45513 0.08 12
SIMILARITY 524226 519840 0.91 1
SUBCELLULAR LOCATION 371796 362592 0.65 3
SUBUNIT 308390 302243 0.54 5
TISSUE SPECIFICITY 52637 51844 0.09 10
TOXIC DOSE 914 722 <0.01 27
WEB RESOURCE 5390 4859 0.01 23
Total number of comment topics: 29
Total Number of Average
Line type / subtype number entries per entry Rank
------------------------------------ -------- --------- --------- ----
Features (FT) 5867111 10.18
ACT_SITE 181831 108030 0.32 10
BINDING 1332180 226887 2.31 1
CARBOHYD 127377 32403 0.22 14
CHAIN 584675 568206 1.01 2
COILED 22917 15859 0.04 25
COMPBIAS 277768 97732 0.48 7
CONFLICT 140585 48932 0.24 13
CROSSLNK 26116 9358 0.05 24
DISULFID 142656 37776 0.25 12
DNA_BIND 12407 11122 0.02 31
DOMAIN 222451 135766 0.39 9
HELIX 446548 35888 0.78 3
INIT_MET 17753 17699 0.03 26
INTRAMEM 3294 1558 0.01 34
LIPID 14304 9116 0.02 28
MOD_RES 269908 75485 0.47 8
MOTIF 50328 32180 0.09 21
MUTAGEN 111836 22208 0.19 15
NON_CONS 2657 833 <0.01 35
NON_STD 361 286 <0.01 36
NON_TER 12615 9709 0.02 30
PEPTIDE 12999 8981 0.02 29
PROPEP 15720 13428 0.03 27
REGION 333809 153312 0.58 6
REPEAT 110794 15365 0.19 16
SIGNAL 45548 45547 0.08 22
SITE 69713 37361 0.12 19
STRAND 426116 33534 0.74 4
TOPO_DOM 155861 31226 0.27 11
TRANSIT 9730 9606 0.02 32
TRANSMEM 386607 81016 0.67 5
TURN 101606 29140 0.18 18
UNSURE 5776 914 0.01 33
VAR_SEQ 53605 22800 0.09 20
VARIANT 107555 17697 0.19 17
ZN_FING 31105 13297 0.05 23
Total number of feature keys: 36
Total Number of Average
Line type / subtype number entries per entry Rank Category
------------------------------------ -------- --------- --------- ---- -------------------------------------------
Cross-references (DR) 21707193 37.68
AbasyAtlas 11770 11770 0.02 97 Gene expression databases
ABCD 3399 3399 0.01 122 Protocols and materials databases
Agora 18461 18412 0.03 85 Miscellaneous databases
AGR 69475 68809 0.12 42 Organism-specific databases
Allergome 2050 1319 <0.01 135 Protein family/group databases
AlphaFoldDB 558587 558587 0.97 9 3D structure databases
Antibodypedia 32433 32324 0.06 61 Protocols and materials databases
AntiFam 22 22 <0.01 171 Family and domain databases
ArachnoServer 1148 1138 <0.01 144 Organism-specific databases
Araport 16441 16345 0.03 90 Organism-specific databases
Bgee 62160 62158 0.11 44 Gene expression databases
BindingDB 8745 8745 0.02 102 Chemistry databases
BioCyc 48376 44318 0.08 53 Enzyme and pathway databases
BioGRID 62877 60839 0.11 43 Protein-protein interaction databases
BioGRID-ORCS 45219 44631 0.08 55 Miscellaneous databases
BioMuta 20283 20256 0.04 73 Genetic variation databases
BMRB 6912 6912 0.01 109 3D structure databases
BRENDA 23415 21128 0.04 67 Enzyme and pathway databases
CarbonylDB 1159 1159 <0.01 143 PTM databases
CARD 328 326 <0.01 160 Protein family/group databases
CAZy 3745 3240 0.01 119 Protein family/group databases
CCDS 49824 34883 0.09 50 Sequence databases
CD-CODE 12402 8900 0.02 96 Miscellaneous databases
CDD 394679 310382 0.69 19 Family and domain databases
CGD 2189 2170 <0.01 132 Organism-specific databases
ChEMBL 10849 10672 0.02 98 Chemistry databases
ChiTaRS 15284 15250 0.03 93 Miscellaneous databases
CIViC 562 561 <0.01 151 Organism-specific databases
ClinPGx 17967 17948 0.03 87 Organism-specific databases
CollecTF 140 140 <0.01 163 Gene expression databases
ComplexPortal 19540 9908 0.03 78 Protein-protein interaction databases
ConoServer 966 878 <0.01 146 Organism-specific databases
CORUM 8248 8248 0.01 104 Protein-protein interaction databases
CPTAC 3472 1929 0.01 120 Proteomic databases
CPTC 410 410 <0.01 155 Protocols and materials databases
CTD 78074 77414 0.14 40 Organism-specific databases
DEPOD 254 254 <0.01 162 PTM databases
dictyBase 4228 4114 0.01 116 Organism-specific databases
DIP 17588 17547 0.03 88 Protein-protein interaction databases
DisGeNET 18619 18488 0.03 82 Organism-specific databases
DisProt 2939 2913 0.01 127 Family and domain databases
DMDM 16164 16163 0.03 92 Genetic variation databases
DNASU 48647 48568 0.08 52 Protocols and materials databases
DrugBank 37137 4996 0.06 60 Chemistry databases
DrugCentral 2983 2983 0.01 126 Chemistry databases
EchoBASE 4158 4158 0.01 117 Organism-specific databases
eggNOG 341177 335272 0.59 20 Phylogenomic databases
ELM 1815 1815 <0.01 136 Protein-protein interaction databases
EMBL 1030361 562966 1.79 3 Sequence databases
EMDB 156666 13088 0.27 29 3D structure databases
Ensembl 182203 51972 0.32 26 Genome annotation databases
EnsemblBacteria 55658 55480 0.10 47 Genome annotation databases
EnsemblFungi 19750 19432 0.03 77 Genome annotation databases
EnsemblMetazoa 19760 12978 0.03 76 Genome annotation databases
EnsemblPlants 26473 6290 0.05 65 Genome annotation databases
EnsemblProtists 1768 1621 <0.01 137 Genome annotation databases
ESTHER 3048 3045 0.01 125 Protein family/group databases
euHCVdb 56 45 <0.01 168 Organism-specific databases
EvolutionaryTrace 22756 22756 0.04 68 Miscellaneous databases
ExpressionAtlas 49604 49604 0.09 51 Gene expression databases
FlyBase 4041 3932 0.01 118 Organism-specific databases
FunCoup 143708 143708 0.25 32 Protein-protein interaction databases
FunFam 548754 328928 0.95 11 Family and domain databases
Gene3D 801884 479493 1.39 6 Family and domain databases
GeneCards 20375 20245 0.04 71 Organism-specific databases
GeneID 320183 294758 0.56 23 Genome annotation databases
GeneReviews 1649 1645 <0.01 138 Organism-specific databases
GeneTree 49983 49968 0.09 49 Phylogenomic databases
GeneWiki 10351 10269 0.02 100 Miscellaneous databases
GenomeRNAi 22326 22325 0.04 69 Miscellaneous databases
GlyConnect 2286 2275 <0.01 131 PTM databases
GlyCosmos 40408 40408 0.07 58 PTM databases
GlyGen 39911 39911 0.07 59 PTM databases
GO 3100768 552254 5.38 1 Ontologies
Gramene 26503 6294 0.05 64 Genome annotation databases
GuidetoPHARMACOLOGY 2361 2361 <0.01 130 Chemistry databases
HAMAP 331132 328195 0.57 22 Family and domain databases
HGNC 20380 20254 0.04 70 Organism-specific databases
HOGENOM 429359 429359 0.75 16 Phylogenomic databases
HPA 19349 19211 0.03 80 Organism-specific databases
IDEAL 1332 1332 <0.01 141 Family and domain databases
IMGT_GENE-DB 267 267 <0.01 161 Protein family/group databases
InParanoid 165131 165131 0.29 28 Phylogenomic databases
IntAct 59191 59191 0.10 45 Protein-protein interaction databases
InterPro 2612851 560452 4.54 2 Family and domain databases
iPTMnet 56794 56794 0.10 46 PTM databases
JaponicusDB 43 43 <0.01 170 Organism-specific databases
jPOST 28438 28438 0.05 62 Proteomic databases
KEGG 521882 485412 0.91 13 Genome annotation databases
Leproma 672 669 <0.01 149 Organism-specific databases
MaizeGDB 529 525 <0.01 152 Organism-specific databases
MalaCards 7439 7426 0.01 107 Organism-specific databases
MANE-Select 18600 18486 0.03 84 Genome annotation databases
MassIVE 19138 19138 0.03 81 Proteomic databases
MDposit 5666 5666 0.01 112 3D structure databases
MDRepo 2104 2104 <0.01 133 3D structure databases
MEROPS 14279 13860 0.02 95 Protein family/group databases
MetOSite 3455 3455 0.01 121 PTM databases
MGI 17199 17156 0.03 89 Organism-specific databases
MIM 24406 16753 0.04 66 Organism-specific databases
MINT 468 468 <0.01 154 Protein-protein interaction databases
MoonDB 348 348 <0.01 159 Protein family/group databases
MoonProt 369 369 <0.01 158 Protein family/group databases
NCBIfam 549356 348539 0.95 10 Family and domain databases
NDEx 10597 10597 0.02 99 Protein-protein interaction databases
NIAGADS 76 76 <0.01 165 Organism-specific databases
OGP 373 373 <0.01 157 2D gel databases
OMA 464108 464108 0.81 15 Phylogenomic databases
OpenTargets 18611 18467 0.03 83 Organism-specific databases
Orphanet 8306 4517 0.01 103 Organism-specific databases
OrthoDB 271550 271550 0.47 24 Phylogenomic databases
PAN-GO 20301 20301 0.04 72 Phylogenomic databases
PANTHER 981284 514515 1.70 4 Family and domain databases
PathwayCommons 19430 19430 0.03 79 Enzyme and pathway databases
PATRIC 93526 93526 0.16 38 Genome annotation databases
PaxDb 169570 169570 0.29 27 Proteomic databases
PCDDB 137 137 <0.01 164 3D structure databases
PDB 399201 39891 0.69 17 3D structure databases
PeptideAtlas 45313 45313 0.08 54 Proteomic databases
PeroxiBase 797 776 <0.01 148 Protein family/group databases
Pfam 891840 553942 1.55 5 Family and domain databases
Pharos 20189 20189 0.04 74 Miscellaneous databases
PHI-base 2842 2226 <0.01 128 Miscellaneous databases
PhosphoSitePlus 42269 42269 0.07 57 PTM databases
PhylomeDB 115921 115921 0.20 35 Phylogenomic databases
PIR 125343 114994 0.22 34 Sequence databases
PIRSF 111228 110054 0.19 36 Family and domain databases
PlantReactome 1436 824 <0.01 140 Enzyme and pathway databases
PomBase 5135 5131 0.01 114 Organism-specific databases
PRIDE 637 637 <0.01 150 Proteomic databases
PRINTS 151993 130423 0.26 31 Family and domain databases
PRO 100244 100244 0.17 37 Miscellaneous databases
ProMEX 489 489 <0.01 153 Proteomic databases
PROSITE 498858 314617 0.87 14 Family and domain databases
Proteomes 396581 378016 0.69 18 Miscellaneous databases
ProteomicsDB 72997 45520 0.13 41 Proteomic databases
PseudoCAP 2081 2081 <0.01 134 Organism-specific databases
Pumba 18201 18201 0.03 86 Proteomic databases
Reactome 153735 39555 0.27 30 Enzyme and pathway databases
REBASE 810 401 <0.01 147 Protein family/group databases
RefSeq 573351 448228 1.00 8 Sequence databases
REPRODUCTION-2DPAGE 1260 1039 <0.01 142 2D gel databases
RGD 8173 8172 0.01 105 Organism-specific databases
RNAct 43122 43122 0.07 56 Miscellaneous databases
SABIO-RK 5959 5959 0.01 111 Enzyme and pathway databases
SASBDB 1094 1094 <0.01 145 3D structure databases
SFLD 27834 9163 0.05 63 Family and domain databases
SGD 6753 6748 0.01 110 Organism-specific databases
SignaLink 19947 19947 0.03 75 Enzyme and pathway databases
SIGNOR 8161 8161 0.01 106 Enzyme and pathway databases
SMART 205615 148940 0.36 25 Family and domain databases
SMR 529529 529529 0.92 12 3D structure databases
STRENDA-DB 59 45 <0.01 166 Enzyme and pathway databases
STRING 337844 337844 0.59 21 Protein-protein interaction databases
SUPFAM 653689 463048 1.13 7 Family and domain databases
SwissLipids 1478 1394 <0.01 139 Chemistry databases
SwissPalm 14336 14336 0.02 94 PTM databases
TAIR 16439 16345 0.03 91 Organism-specific databases
TCDB 8907 8806 0.02 101 Protein family/group databases
TopDownProteomics 3236 2957 0.01 123 Proteomic databases
TubercuList 2376 2340 <0.01 129 Organism-specific databases
UCSC 51171 46669 0.09 48 Genome annotation databases
UniLectin 385 385 <0.01 156 Protein family/group databases
UniPathway 140919 127227 0.24 33 Enzyme and pathway databases
VEuPathDB 88251 80594 0.15 39 Organism-specific databases
VGNC 5170 5158 0.01 113 Organism-specific databases
WBParaSite 56 54 <0.01 167 Genome annotation databases
WormBase 6941 5099 0.01 108 Organism-specific databases
Xenbase 4764 4764 0.01 115 Organism-specific databases
YCharOS 47 47 <0.01 169 Protocols and materials databases
ZFIN 3227 3225 0.01 124 Organism-specific databases
Total number of cross-referenced databases: 171
6. AMINO ACID COMPOSITION
6.1 Composition in percent for the complete database
Ala (A) 8.25 Gln (Q) 3.93 Leu (L) 9.64 Ser (S) 6.66
Arg (R) 5.52 Glu (E) 6.71 Lys (K) 5.79 Thr (T) 5.36
Asn (N) 4.06 Gly (G) 7.07 Met (M) 2.41 Trp (W) 1.10
Asp (D) 5.46 His (H) 2.27 Phe (F) 3.86 Tyr (Y) 2.92
Cys (C) 1.38 Ile (I) 5.90 Pro (P) 4.75 Val (V) 6.85
Asx (B) 0.000 Glx (Z) 0.000 Xaa (X) 0.00
Legend: gray = aliphatic, red = acidic, green = small hydroxy,
blue = basic, black = aromatic, white = amide, yellow = sulfur
6.2 Classification of the amino acids by their frequency
Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
Phe, Tyr, Met, His, Cys, Trp
7. MISCELLANEOUS STATISTICS
4467 entries are encoded on a mitochondrion, and 4076 are encoded on a plasmid.
12200 entries are encoded on a plastid,
of which 23 are encoded on apicoplasts,
11633 on chloroplasts,
51 on organellar chromatophores,
145 on cyanelles,
149 on non-photosynthetic plastids and
199 on unspecified types of plastid.
Number of entries with at least one sequence correction: 81841