At CRCI²NA (Nantes - Angers Cancer and Immunology Research Center), the ICAGEN (Integrated CAncer GENomics) team studies mechanisms of cancer development and treatment resistance through integrated genomic approaches. In multiple myeloma, we investigate the genetic and epigenetic changes that drive disease progression and resistance, with a focus on innovative immunotherapies such as CAR-T cells and bispecific antibodies. By integrating multiomics, bulk and single-cell profiling, and computational analyses, we uncover how tumors evolve and interact with the immune system.
Latest publications
- Mechanisms of resistance to bispecific T-cell engagers in multiple myeloma and their clinical implications Letouzé E, Moreau P, Munshi N, Samur M, Minvielle S, Touzeau C Blood Advances 2024. Jun 11;2952‑59
- Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation Derrien J, Gastineau, S, Frigout A, Giordano N, Cherkaoui M, Gaborit V, Boinon R, Douillard E, Devic M, Magrangeas F, Moreau P, Minvielle S, Touzeau C, Letouzé E Nat Cancer 2023. Aug 31;1-8
- Exploring the Impact of Dexamethasone on Gene Regulation in Myeloma Cells Bessonneau-Gaborit V, Cruard J, Guérin-Charbonnel C, Derrien J, Alberge JB, Douillard E, Devic M, Roi N, Campion L, Westermann F, Moreau P, Herrmann C, Bourdon J, Magrangeas F, Minvielle S Life Science Alliance 2023 Jul 30;6(9) e202302195
Latest communications
- [Poster] Integrative Bulk and Single-Cell Multiomic Framework for Tracing (Sub)clonal Evolution in Multiple Myeloma Nils Giordano, Marie Denoulet, Mia Cherkaoui, Élise Douillard, Magali Devic, Florence Magrangeas, Philippe Moreau, Cyrille Touzeau, Stephane Minvielle, Eric Letouzé Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM 2025), Jul 2025, Bordeaux, France. ⟨hal-05118693⟩
- [Poster] Detection of Somatic Copy Number Alterations from Single-cell Multiomics Data With the R Package muscadet Marie Denoulet, Nils Giordano, Mia Cherkaoui, Elise Douillard, Magali Devic, Florence Magrangeas, Stéphane Minvielle, Céline Vallot, Eric Letouzé Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM 2025), Jul 2025, Bordeaux, France. ⟨hal-05150254⟩