Rosetta Commons drives innovation in biomolecular modeling and design through cutting-edge computational methods and shared software. Our global community of scientists collaborates to advance open, reproducible science and accelerate discovery.

This GitHub organization hosts the tools our community has built – from the original physics-based Rosetta software to the latest ML-driven methods for protein design.

• Physics-based tools: The original Rosetta suite for structure prediction, docking, and design
• ML-based tools: Community-built deep learning methods developed over the past several years
• Support resources: Documentation and community guidance for every experience level

Not sure where to begin? The Software Download page has an overview of all available repositories with their support levels, so you can find the right tool for your pipeline. For broader context on our organization and mission, visit the Rosetta Commons website.